Structure-Based Design of an Iminoheterocyclic Β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor That Lowers Central Aβ in Nonhuman Primates. Mihirbaran Mandal , Yusheng Wu , Jeffrey Misiaszek , Guoqing Li , Alexei Buevich , John P. Caldwell , Xiaoxiang Liu , Robert D. Mazzola , Peter Orth , Corey Strickland , Johannes Voigt , Hongwu Wang , Zhaoning Zhu , Xia Chen , Michael Grzelak , Lynn A. Hyde , Reshma Kuvelkar , Prescott T. Leach , Giuseppe Terracina , Lili Zhang , Qi Zhang , Maria S. Michener , Brad Smith , Kathleen Cox , Diane Grotz , Leonard Favreau , Kaushik Mitra , Irina Kazakevich , Brian A. McKittrick , William Greenlee , Matthew E. Kennedy , Eric M. Parker , Jared N. Cumming , Andrew W. Stamford Journal of Medicinal Chemistry（2016）
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