Synthesis, Insecticidal And Fungicidal Activities Of Methyl 2-(Methoxyimino)-2-(2-((1-(N '-Nitrocarbamimidoyl)-2-Hydrocarbylidene-Hydrazinyl)Methyl)Phenyl) Acetates

RSC ADVANCES(2016)

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Abstract
N'-Nitro-2-hydrocarbylidenehydrazinecarboximidamides and methoxyacrylates are two types of important agrochemicals. By combining their key fragments into one framework, a series of the title compounds was designed and synthesized. Some of these compounds have shown excellent insecticidal activities for aphides, for example, the LC50 values of compounds 6-06, 6-11 and 6-19 against M. perslcae and H. amygdale were found to be 1.9/14.4, 13.4/1.5 and 0.3/38.4 mg L-1 respectively. They were also effective against the mycelium growth of B. cinerea in vitro. Compound 6-04 could control (similar to 100%) cucumber anthrax and rice blast at 100 mg L-1 in vivo, and inhibit the spore germination (similar to 100%) of vegetable gray mold at 6.25 mg L-1. These compounds could be considered as potential insecticidal or fungicidal candidates for crop protection. The results of structure-activity relationship (SAR) studies are discussed.
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Key words
insecticidal,fungicidal activities,synthesis,2-methoxyimino-2-2-1-n′-nitrocarbamimidoyl-2-hydrocarbylidenehydrazinylmethylphenylacetates
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