Reconstruction of gene regulatory modules from RNA silencing of IFN-α modulators: experimental set-up and inference method
BMC Genomics(2016)
Abstract
Inference of gene regulation from expression data may help to unravel regulatory mechanisms involved in complex diseases or in the action of specific drugs. A challenging task for many researchers working in the field of systems biology is to build up an experiment with a limited budget and produce a dataset suitable to reconstruct putative regulatory modules worth of biological validation.
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Key words
IFN-α modulators,Gene regulatory modules,RNA silencing,Experimental set-up,Small-scale gene expression screens
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