Glycation Reactivity of a Quorum-Sensing Signaling Molecule
Angewandte Chemie(2016)
摘要
Reported herein is that (4S)-4,5-dihydroxy-2,3-pentanedione (DPD) can undergo a previously undocumented non-enzymatic glycation reaction. Incubation of DPD with viral DNA or the antibiotic gramicidin S resulted in significant biochemical alterations. A protein-labeling method was consequently developed that facilitated the identification of unrecognized glycation targets of DPD in a prokaryotic system. These results open new avenues toward tracking and understanding the fate and function of the elusive quorum-sensing signaling molecule.
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关键词
fluorescent probes,glycation,protein modifications,proteomics,quorum sensing
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