Asymmetric α-chlorination of β-ketoesters using bifunctional ammonium salt catalysis
Monatshefte Fur Chemie(2015)
Abstract
Chiral urea-quaternary ammonium salt hybrid organocatalysts were tested for their capability to control asymmetric α-chlorination reactions of β-ketoesters. After a careful screening we identified a structurally simple catalyst derivative that allowed us to obtain enantiomeric ratios up to 90:10 under operationally simple conditions using just 1 mol% of the catalyst. Graphical abstract
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Key words
Organocatalysis,Phase-transfer catalysis,H-bonding activation,Ion pairing
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