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Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway

Rui Yamaguchi,Takatoshi Yamamoto,Arisa Sakamoto,Yasuji Ishimaru,Shinji Narahara,Hiroyuki Sugiuchi,Yasuo Yamaguchi

Blood Cells, Molecules, and Diseases（2016）

Cited 8|Views3
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Abstract
Granulocyte-macrophage colony stimulating factor (GM-CSF) induces procoagulant activity of macrophages. Tissue factor (TF) is a membrane-bound glycoprotein and substance P (SP) is a pro-inflammatory neuropeptide involved in the formation of membrane blebs. This study investigated the role of SP in TF release by GM-CSF-dependent macrophages.
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Key words
ELISA,GM-CSF,GRK2,NK1R,PDTC,PKC,Rho A,ROCK,siRNA,SP,TF
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