17β-Hydroxysteroid dehydrogenase type 10 predicts survival of patients with colorectal cancer and affects mitochondrial DNA content

Albert Amberger,Andrea J. Deutschmann,Pia Traunfellner,Patrizia Moser,René G. Feichtinger,Barbara Kofler,Johannes Zschocke

Cancer Letters（2016）

引用 3|浏览11

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摘要

•We examined expression of HSD10 in colorectal cancer.•HSD10 is an independent prognostic marker for survival.•HSD10 expression correlates with mitochondrial DNA content in cancer.•Decreased HSD10 expression causes mitochondrial DNA depletion in cancer cells.

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关键词

Colorectal cancer,Mitochondrial DNA,Survival,17β-Hydroxysteroid dehydrogenase type 10,Prognostic marker

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