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Dihydropyrano [2,3-c] pyrazole: Novel in vitro inhibitors of yeast α-glucosidase

Hamdy Kashtoh,Munira Taj Muhammad,Jalaluddin J.A. Khan,Saima Rasheed,Ajmal Khan,Shahnaz Perveen,Kulsoom Javaid,Atia-tul-Wahab,Khalid Mohammed Khan,M. Iqbal Choudhary

Bioorganic Chemistry（2016）

Cited 50|Views14
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Abstract
•Synthesis of dihydropyrano [2,3-c] pyrazole derivatives.•In vitro yeast α-glucosidase inhibitory activity.•Seven compounds i.e. 1, 2, 4, 19, 22, 30, and 33 were found to possess α-glucosidase active.•Structure–activity relationship has been established.
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Dihydropyrano [2,3-c] pyrazole,α-Glucosidase inhibition,Post-prandial hyperglycemia,Diabetes
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