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GATA2-deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in humans.

Avanti Desai,Kathryn Sowerwine,Yihui Liu,Monica G Lawrence,Jack Chovanec,Amy P Hsu,Michael P O'Connell,Jiwon Kim,Lisa Boris,Nina Jones,Laura Wisch,Robin R Eisch,Melody C Carter,Hirsh D Komarow,Christa Zerbe,Joshua D Milner,Irina Maric,Xiaoping Sun,Chyi-Chia R Lee,Ilker Tunc,Mehdi Pirooznia,Kelly D Stone,Steven M Holland,Dean D Metcalfe,Jonathan J Lyons

Journal of Allergy and Clinical Immunology（2019）

Cited 18|Views90
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Abstract
GATA2 deficient patients have a low prevalence of allergic disease resulting from impaired IgE-mediated mast cell activation; thus, GATA2 represents a novel therapeutic target for clinical allergy.
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Key words
FcεRI,GATA2,IgE,KIT,SCF,allergy,mast cell activation
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