Downregulation of aspartoacylase during the progression of myelin breakdown in the dmy mutant rat with mitochondrial magnesium channel MRS2 defect.

Mitsuru Kuwamura, Satomi Tanimura,Yuko Hasegawa, Rika Hoshiai,Yushi Moriyama,Miyuu Tanaka,Shigeo Takenaka,Haruna Nagayoshi,Takeshi Izawa,Jyoji Yamate,Takashi Kuramoto,Tadao Serikawa

Brain Research（2019）

引用 3|浏览19

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摘要

•We focused on the aspartoacylase (ASPA) and mitochondrion-related metabolites to clarify the mechanism of myelin pathology in dmy rats.•Aspa mRNA and ASPA protein was significantly decreased in the dmy rats.•It is intriguing that prior to the myelin destruction disrupted expression of Aspa mRNA and ASPA protein undergoes from early stage of myelinogenesis.

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关键词

Dysmyelination,Mutant rat,Oligodendrocyte,Aspartoacylase,Mitochondria

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