Studies on quinazolines 7*. Alkylation of 2-aryl-4,4-diphenyl-3,4-dihydroquinazolines with methyl iodide

The reaction of 2-aryl-4,4-diphenyl-3,4-dihydroquinazoline with methyl iodide in acetone in the presence of potassium hydroxide at 40°C leads to the formation of the corresponding 1-methyl-4,4-diphenyl-1,4-dihydroquinazolines and 1,3-dimethyl-4,4-diphenyl-1,4-dihydroquinazolin-3-ium iodides. The structure of 2-(7-methoxy-1,3-benzodioxol-5-yl)-1-methyl-4,4-diphenyl-1,4-dihydroquinazoline was established by heteronuclear correlation NMR spectroscopy.