Multidrug-Resistant Acinetobacter Baumannii Infection In Lung Transplant Recipients: Risk Factors And Prognosis

Backgrounds: Infectious complication is an important cause of poor outcome of lung transplantation (LT). Infections with Acinetobacter baumannii (A. baumannii) are problematic, because of limited therapeutic option due to increasing resistance to antibiotics. However, there are few studies on A. baumannii infection in lung transplant recipients. Thus, we aimed to investigate epidemiology and risk factors for infection with A. baumannii in lung transplant recipients.Methods: Lung transplant recipients >= 18 years of age in a university hospital were enrolled in this retrospective cohort study. Risk factors for infection with multidrug resistant A. baumannii and 90-day mortality were analysed.Results: Fifty-one of 96 lung transplant recipients experienced A. baumannii infection. Infected patients had a significantly higher 90-day mortality rate than uninfected (19.6% vs. 2.2%, p=.009). High blood urea nitrogen (BUN) before transplantation (odds ratio [OR] 1.16; p=.008), long duration of surgery (OR 1.16; p=.029) and hypoalbuminemia before transplantation (OR 4.01; p=.037) were independent risk factors for infection with multidrug resistant A. baumannii. On multivariate analysis, severe thrombocytopenia (OR 28.69; p=.005), high serum creatinine (OR 1.48; p=.042) and infection with multidrug resistant A. baumannii (OR 22.58; p=.031) were independent risk factors for 90-day mortality.Conclusions: Prolonged surgery, high BUN and hypoalbuminemia before LT were significant risk factors for infection with multidrug resistant A. baumannii. Severe thrombocytopenia, high serum creatinine and infection with multidrug resistant A. baumannii infection were independent risk factors for 90-day mortality.