mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials.

Robert A Feldman,Rainard Fuhr,Igor Smolenov, Amilcar Mick Ribeiro,Lori Panther,Mike Watson,Joseph J Senn,Mike Smith,Ӧrn Almarsson,Hari S Pujar,Michael E Laska,James Thompson,Tal Zaks,Giuseppe Ciaramella

Vaccine（2019）

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摘要

•mRNA vaccines may provide timely and effective responses to threats from emerging pathogens.•We assessed mRNA vaccines against 2 highly pathogenic avian influenza strains.•The first mRNA N10N8 and H7N9 influenza vaccines are safe and immunogenic.

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关键词

mRNA,Vaccines,Pandemic influenza,Safety,Immunogenicity

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