Xenobiotic transporter activity in zebrafish embryo ionocytes.

Wei E Gordon,Jose A Espinoza, Dena M Leerberg,Deborah Yelon,Amro Hamdoun

Aquatic Toxicology（2019）

引用 14|浏览7

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摘要

•Zebrafish embryo ionocytes are specialized epidermal cells involved in ion transport/homeostasis.•Ionocytes actively transport fluorescent small molecules known to be substrates of xenobiotic transporters.•An ABC transporter, ABCB5, is expressed in the HR ionocyte subtype, consistent with the observed efflux activity.•Transporter activity in the ionocytes could help eliminate toxic small molecules from the zebrafish embryo.

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关键词

Ionocytes,Zebrafish,Embryo,Xenobiotic transporter (XT),ATP-binding cassette (ABC) transporter,P-glycoprotein (P-gp),Multidrug resistance protein (MRP),Calcein

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