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Study on the Prognostic Value of Aberrant Antigen in Patients With Acute B Lymphocytic Leukemia.

Jun Liu,Xu Tan,Ying-Ying Ma,Yao Liu,Li Gao,Lei Gao,PeiYang Kong,Xian-Gui Peng,Xi Zhang,Cheng Zhang

Clinical Lymphoma Myeloma and Leukemia（2019）

Cited 9|Views37
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Abstract
Therefore, in the construction of CAR-T cells in patients with R/R B-ALL, conventional CD19 can be combined with aberrant antigens such as CD123 to form CARs with bi-specific antigens or multi-specific antigens may achieve the purpose of improving efficacy. However, more clinical trials are needed.
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Key words
Aberrant antigen,Acute B lymphocytic leukemia,CAR-T cells,Flow Cytometry,Prognostic value
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