Co(iii)-catalyzed Z-selective oxidative C-H/C-H cross-coupling of alkenes with triisopropylsilylacetylene.
CHEMICAL COMMUNICATIONS(2019)
Abstract
A Co(III)-catalyzed direct oxidative C-H/C-H cross-coupling reaction of acrylamides with triisopropylsilylacetylene is presented. It is applicable to unsubstituted, internal and terminal acrylamides with a broad functionality tolerance. The feasibility of this protocol is successfully demonstrated by the late-stage alkynylation of a derivative of steroid drug Epristeride.
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Key words
triisopropylsilylacetylene,alkenes,cross-coupling
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