Evolving methods for rational de novo design of functional RNA molecules.
Methods(2019)
Abstract
•Summarizes commonly used strategies to computationally design functional RNAs.•The complete approach from initial analysis to predictions and wet-lab experiments.•Computational design programs are thoroughly dissected into their algorithmic components.•Experimental methods for design verification and characterization are discussed.
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Key words
RNA design,Rational de novo design,Synthetic biology,Artificial RNA devices,Mechanistic models,Sequence sampling,Experimental validation,RNA design tools
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