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REPRODUCTIVE EVALUATIONS IN FEMALE RAT OFFSPRING EXPOSED TO METFORMIN DURING INTRAUTERINE AND INTRAUTERINE/LACTATIONAL PERIODS.

Simone Forcato,Bruno Garcia Montagnini,Maria Luiza Marino de Góes, Daniella Regina Barrionuevo da Silva Novi,Ana Carolina Inhasz Kiss,Graziela Scalianti Ceravolo,Daniela Cristina Ceccatto Gerardin

Reproductive Toxicology（2019）

Cited 9|Views7
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Abstract
•Maternal exposure to MET did not alter the reproductive behavior of female pups.•An increase in plasmatic estradiol levels was observed only in the METGL group.•The reproductive alteration might be related to programming in ovarian cells.
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MET,AMPK,GLP -1,OCT,GnRH,FSH,LH,CTRG,GD,LD,METG,CTRGL,METGL,SHBG,ERα,DOHaD,PND,AGD,RMANOVA,PCOS
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