Transient Receptor Potential Melastatin 4 Contributes to Early-Stage Endothelial Injury Induced by Arsenic Trioxide.

•Our studies have strongly suggested for the first time that TRPM4 is the target gene in ATO-induced endothelial cell injury.•Our studies shed light on how important of TRPM4 inhibition contributes to early-stage endothelial injury induced by ATO.•TRPM4 may be a important molecular target for future clinical management ATO-induced endothelial injury.