Cardiotonic steroid ouabain stimulates steroidogenesis in Leydig cells via the α3 isoform of the sodium pump.
The Journal of Steroid Biochemistry and Molecular Biology(2019)
摘要
•We demonstrate hormone-like actions of ouabain on a Leydig cell line.•We show ouabain-induced activation of Erk1/2, CREB and ATF-1.•Ouabain triggers mobilization of LDs and PLIN2 and stimulates steroidogenesis.•Silencing expression of the α3 isoform of the sodium pump prevents all the above.•The results imply that ouabain-induced signaling might be part of male physiology.
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关键词
Sodium pump,Leydig cells,Ouabain,Lipid droplet,Perilipin,Steroidogenesis
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