Fusion cytokine IL-2-GMCSF enhances anticancer immune responses through promoting cell–cell interactions
Journal of Translational Medicine(2016)
Abstract
Potent antitumor responses can be induced through cytokine immunotherapy. Interleukin (IL)-2 and granulocyte–macrophage colony-stimulating factor (GM-CSF) are among the most effective cytokines to induce tumor-specific systemic immune responses and can act synergistically. To overcome the limitations of combined use of these two cytokines, we have constructed an IL2-GMCSF fusion protein and characterized its antitumor effects in this study.
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Key words
Interleukin-2,Granulocyte–macrophage colony-stimulating factor,Fusion protein,Antitumor,Cell–cell interaction
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