Tamoxifen restores extracellular trap formation in neutrophils from patients of chronic granulomatous disease, in ROS-independent manner.

Atul Sharma,Katelyn McCann,Jitendra Kumar Tripathi,Pooja Chauhan,Christa Zerbe,Bibhuti B Mishra,Steven M Holland,Jyotika Sharma

Journal of Allergy and Clinical Immunology（2019）

引用 6|浏览24

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摘要

Tamoxifen induces autophagy-dependent NET formation in CGD patient neutrophils and improves their antimicrobial activity. Given the genetic defect in their ROS-generation machinery, this study highlights repurposing of tamoxifen to potentiate host defense in CGD patients.

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关键词

Autophagy,Chronic Granulomatous Disease,Neutrophils extracellular traps,Tamoxifen

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