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Lactic acid suppresses IgE-mediated mast cell function in vitro and in vivo

Daniel Abebayehu,Andrew J. Spence,Heather Caslin,Marcela Taruselli,Tamara T. Haque,Kasalina N. Kiwanuka,Elizabeth Motunrayo Kolawole,Alena P. Chumanevich,Scott A. Sell,Carole A. Oskeritzian,John Ryan,Sydney Ann Kee

Cellular Immunology（2019）

Cited 12|Views22
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Abstract
•LA suppresses IgE-induced mast cell inflammatory functions in vitro and in vivo.•LA effects require acid pH and expression of the proton-dependent transporter MCT-1.•LA suppresses early IgE receptor-induced phosphorylation events.
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BMMC,DNP-HAS,LA,MCT-1,PMC,PSA,SCF,SkMC
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