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Limited adaptation of chimeric H9N2 viruses containing internal genes from bat influenza viruses in chickens.

Chaochao Ren,Yinyin Chen,Min Zhang,Ting Zhang,Danqi Bao,Chenyang Lu,Ruixue Xue, Yanjie Zhang,Wenhua Liu,Hongjun Chen,Qiaoyang Teng,Jianmei Yang,Xuesong Li,Zejun Li,Qinfang Liu

Veterinary Microbiology（2019）

Cited 4|Views30
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Abstract
•Two modified cH9cN2/H17 and cH9cN2/H18 containing HA and NA ORFs of H9N2 were generated in the background of the bat influenza viruses.•cH9cN2/H17 and cH9cN2/H18 replicated poorly in chicken cells and NS1 protein of H18N11 showed stronger IFN-I antagonism activity than H17N10.•cH9cN2/H18 virus was transmissible in chickens, but not cH9cN2/H17, indicated that the internal genes of H18N11 seems to adapt chickens better.
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Key words
Bat influenza virus,H17N10,H18N11,H9N2
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