Cytotoxin 1 from Naja atra Cantor venom induced necroptosis of leukemia cells.

Yamin Liu,Wei Ming,Yan Wang,Sihong Liu,Yanfen Qiu,Yongxin Xiang,Lili Hu,Lingjie Fan,Xiang Peng,Han Wang,Tianhan Kong,Weihua Dong,Qifeng Guo

Toxicon（2019）

引用 15|浏览10

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摘要

•CTX1 mainly induced late apoptosis and necrosis in HL-60 and KG1a.•CTX1 induced cell death could be rescued by necroptosis inhibitor Nec-1.•CTX1 increased lysosome membrane permeability and release of cathepsin B.

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关键词

CTX1,Necroptosis,Lysosome cell death,Leukemia

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