Idiosyncratic drug-induced liver injury linked to Polygonum multiflorum : A case study by pharmacognosy

The use of Chinese medicinal herbs（CMH）continues to expand rapidly across the world with a deep belief that herbs are safe because they are"natural".（1）However,a survey of the literature indicates that CMH related hepatotoxicity is increasing and has been a worldwide problem.（2,3）Polygonum multiflorum Thunb.（P.multiflorum）,officially listed in the Pharmacopoeia of the People’s Republic of China,（4）has been used effectively for thousands of years in China