The presence and variant allele fraction of EGFR mutations in ctDNA and development of resistance.

Grainne M O'Kane,Geoffrey Liu,Tracy L Stockley,Muqdas Shabir,Tong Zhang,Jennifer H Law,Lisa W Le,Adrian Sacher,Frances A Shepherd,Penelope A Bradbury,Natasha B Leighl

Lung Cancer（2019）

引用 17|浏览16

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摘要

•Multi-gene NGS panels can be used to detect mutations and the %VAF in liquid biopsies.•The presence of EGFR mutations in ctDNA may predict a shorter progression free survival interval.•A high % variant allele fraction of mutations may indicate progressive disease.

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关键词

EGFR mutation,Non-small cell lung cancer,Resistance,Variant allelic fraction

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