Right ventricular pressure overload alters cardiac lipid composition

A.M.C. Koop,Q.A.J. Hagdorn, G.P.L. Bossers, T. van Leusden,A. Gerding,M. van Weeghel,F.M. Vaz,D.P.Y. Koonen,H.H.W. Silljé,R.M.F. Berger,B. Bartelds

International Journal of Cardiology（2019）

引用 8|浏览22

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摘要

•Right ventricular (RV) pressure load induces early RV dysfunction.•Altered lipid composition accompanies RV dysfunction.•Lipid decreases in RV pressure load are driven by poly-unsaturated fatty acids.•Decrease of cardiolipins and diglycerides precede mitochondrial dysfunction.•RV dysfunction is associated with early upregulation of oxidative stress markers.

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关键词

Right ventricular dysfunction,Hypertrophy,Metabolism,Diglyceride,Cardiolipin

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