NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.
Life Sciences（2019）
Abstract
•The NLRP3 inflammasome was activated and the IL-23/IL-17 axis was upregulated after tMCAO.•The NLRP3 inflammasome was suppressed by MCC950 in mice after tMCAO.•Inhibition of the NLRP3 inflammasome by MCC950 attenuated the ischaemia-reperfusion injury after tMCAO.•Inhibition of the NLRP3 inflammasome by MCC950 reduced the activation of IL-23/IL-17 axis after tMCAO.
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Key words
NLRP3 inflammasome,Interleukin-23/Interleukin-17 (IL-23/IL-17),Interleukin-23 receptor (IL-23R),Ischaemia-reperfusion injury
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