Aids Prevention And Control In The Yunnan Region By T Cell Subset Assessment

BackgroundPrior to being spread throughout broader China, multiple human immunodeficiency virus (HIV)-1 genotypes were originally discovered in the Yunnan Province. As the HIV-1 epidemic continues its spread in Yunnan, knowledge of the influence of gender, age, and ethnicity to instances of HIV reservoirs will benefit monitoring the spread of HIV.MethodsThe degree to which T cells are depleted during an HIV infection depends on the levels of immune activation. T-cell subsets were assessed in newly-diagnosed HIV/AIDS patients in Yunnan, and the influence of age, gender, and ethnicity were investigated. Patients that were newly diagnosed with the HIV-infection between the years 2015 and 2018 at the First Affiliated Hospital of Kunming Medical College were selected for this study (N = 408). The lymphocyte levels and T cell subsets were retrospectively measured in whole blood samples by FACS analysis.ResultsThe median CD4 count was 224 +/- 191 cells/mu l. Significantly higher mean frequencies and absolute numbers were observed in CD3(+), CD3(+) CD4(+), CD3(+) CD8(+), CD45(+), and CD3(+) CD4(+)/CD45(+) in females compared to males. Han patients showed a higher total number of CD3+ T cells and the ratio of CD3(+)/CD45(+) cells compared to any other ethnic minority (P < 0.001). The numbers of CD3(+) T-cells, CD3(+) CD8(+) T cells, and CD45(+) T cells were highest in the age group >= 60. Significant differences were observed in the counts of CD3(+), CD3(+) CD8(+), and CD45(+) cells and the ratio of CD3(+)/CD45(+) and CD3(+) CD4(+)/CD45(+) cells between the. 29 and 30-59 age groups.ConclusionThis study has revealed that low levels of CD4(+) T cells can be observed in newly-diagnosed HIV/AIDS patients in the Yunnan province. It has also been demonstrated that gender, age, and ethnicity have a significant association with the ratio of T-cell subsets that may contribute to virus progression and disease prognosis in individuals belonging to certain subsets of the population. This study has highlighted the importance of HIV/AIDS screening in at-risk populations to ensure timely and adequate clinical management in Yunnan.