Enantioselective Gold(I)-Catalyzed Heterocyclization–Intermolecular Exo [4 + 3]-Cycloaddition Reactions for the Synthesis of Chiral Oxa-Bridged Benzocycloheptanes
Organic Letters(2019)
摘要
The highly exo- and enantioselective gold-catalyzed tandem heterocyclization/[4 + 3] cycloaddition of 2-(1-alkynyl)-2-alken-1-ones and 1,3-diphenylisobenzofuran was implemented by utilizing Ming-Phos, which provides a facile access to chiral seven-membered oxa-bridged rings in 80–98% yield with high exo selectivity (exo/endo up to 50:1) and up to 97% ee.
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关键词
heterocyclization–intermolecular exo,synthesis,]-cycloaddition,oxa-bridged
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