Eltrombopag Promotes DNA Repair in Human Hematopoietic Stem and Progenitor Cells.

Kacey L Guenther, Patali S Cheruku,Ayla Cash,Richard H Smith,Luigi J Alvarado,Sandra Burkett,Danielle M Townsley,Thomas Winkler,Andre Larochelle

Experimental Hematology（2019）

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摘要

•Eltrombopag promotes C-NHEJ DNA repair in human HSPCs.•Eltrombopag-mediated DNA repair results in enhanced HSPC genome stability.•Eltrombopag-mediated DNA repair promotes HSPC survival and function.•Eltrombopag may prevent HSPC injury induced by IR in cancer therapy.•Eltrombopag may offer a new therapeutic modality for genome instability syndromes.

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关键词

DNA repair,Eltrombopag,Hematopoietic stem cells,Thrombopoietin

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