Abstract # 3223 Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation

•Poly(I:C) potassium salt from the same vendor shows batch-to-batch variability.•Poly(I:C) batch-to-batch variability affects immunogenicity and thermoregulation.•Poly(I:C) batch-to-batch variability influences spontaneous abortion rates.•Poly(I:C) variability is related to the molecular weight of dsRNA fragments.•Poly(I:C) quality assessment is pivotal for maternal immune activation models.