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Nicotine improved the olfactory impairment in MPTP-induced mouse model of Parkinson's disease

Jing Yang,Dong-Jun Lv,Ling-Xi Li,Ya-Li Wang,Di Qi,Jing Chen,Cheng-Jie Mao,Fen Wang,Yi Liu,Li-Fang Hu,Chun-Feng Liu

NeuroToxicology（2019）

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Abstract
•Cholinergic damage in the OB might contribute to the olfactory dysfunction.•Nicotine could improve the olfactory impairment in MPTP-treated mice.•Nicotine enchance choline acetyltransferase activity in the OB of MPTP-treated mice.
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Key words
Parkinson’s disease,Olfactory dysfunction,Nicotine,cHolinergic system
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