The impact of HIV exposure on respiratory syncytial virus-associated severe respiratory illness in South African infants, 2011-2016.

Meredith L McMorrow,Stefano Tempia,Sibongile Walaza,Florette K Treurnicht,Jocelyn Moyes,Adam L Cohen,Marthi Pretorius,Orienka Hellferscee,Nicole Wolter,Anne von Gottberg,Arthemon Nguweneza,Johanna M McAnerney,Fathima Naby,Omphile Mekgoe,Marietjie Venter,Shabir A Madhi,Cheryl Cohen

CLINICAL INFECTIOUS DISEASES（2019）

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摘要

From 2011 through 2016, we conducted surveillance for severe respiratory illness in infants. Human immunodeficiency virus exposure significantly increased the risk of respiratory syncytial virus (RSV)-associated hospitalization in infants aged <5 months. More than 60% of RSV-associated hospitalizations occurred in the first 4 months of life and may be preventable through maternal vaccination or birth-dose monoclonal antibody.

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respiratory syncytial virus,human immunodeficiency virus,incidence,South Africa

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