IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states.
EBioMedicine(2019)
摘要
IgE can engage and re-educate alternatively-activated macrophages towards pro-inflammatory phenotypes and prime all subsets to mediate anti-tumour functions. This points to IgE-mediated cascades with potential to activate immune stroma and may be significant in the clinical development of strategies targeting tumour-resident macrophages.
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关键词
Cancer immunotherapy,Pellizzari et al.
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