Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways.

Guannan Meng,Xiaoya Zhou,Menglong Wang,Liping Zhou,Zhenya Wang,Meng Wang,Jielin Deng,Yuhong Wang,Zhen Zhou,Yifeng Zhang,Yanqiu Lai,Qianqian Zhang,Xiaomeng Yang,Lilei Yu,Hong Jiang

EBioMedicine（2019）

引用 22|浏览14

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摘要

The gut microbe-derived metabolite TMAO can activate the CSNS and aggravate ischemia-induced VA via the direct pathway through the LSG and the indirect pathway through central autonomic activation. FUND: This work was supported by the National Key R&D Program of China [2017YFC1307800], and the National Natural Science Foundation of China [81530011, 81770364, 81570463, 81871486, 81600395, 81600367 and 81700444].

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关键词

Gut microbes,Trimethylamine N-oxide,Cardiac autonomic nervous system,Left stellate ganglion,Ventricular arrhythmia

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