Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla.

Yosuke Tanaka,Soichiro Sonoda,Haruyoshi Yamaza,Sara Murata,Kento Nishida,Yukari Kyumoto-Nakamura,Norihisa Uehara,Kazuaki Nonaka,Toshio Kukita,Takayoshi Yamaza

Journal of Endodontics（2019）

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摘要

•Acetylsalicylic acid promotes the in vitro and in vivo odontogenic differentiation of stem cells from the apical papilla (SCAPs).•Acetylsalicylic acid suppresses the phosphoinositide 3-kinase–AKT pathway in SCAPs during the odontogenic differentiation.•Acetylsalicylic acid could provide a novel adjuvant in regenerative endodontics.

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关键词

Acetylsalicylic acid,AKT,odontogenic differentiation,stem cells from apical papilla

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