Recurrent Skin Langerhan Cell Histiocytosis Successfully Treated With Indomethacin Monotherapy
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY(2020)
Abstract
Langerhans cell histiocytosis (LCH) often has a recurrent and refractory course despite multiagent treatment modalities. Common relapse treatments include intense or prolonged cytotoxic chemotherapy regimens. There are a few prior reports that the nonsteroidal anti-inflammatory drug indomethacin demonstrated activity against bone LCH. Here we report indomethacin as a successful treatment for a case of chronic skin LCH that failed multiple prior chemotherapy regimens. This experience supports the need for trials to investigate indomethacin as a treatment for LCH both in the relapsed or refractory setting as well as potential combination or maintenance therapy in newly diagnosed patients.
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Key words
Langerhan cells,nonsteroidal anti-inflammatory drug,indomethacin monotherapy,refractory histiocytosis
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