Pharmacokinetic study on bruceoside A revealed the potential role of quassinoid glycosides for the anticancer properties of Fructus Bruceae.

Yuan Xu,Mingming Xu,Lin Zhang,Zhenhua Zhu,Sheng Guo,Shulan Su,Jianming Guo,Chun-Tao Che,Zhi-Xiu Lin,Ming Zhao,Jin-Ao Duan

Journal of Pharmaceutical and Biomedical Analysis（2019）

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Abstract

•Pharmacokinetic study of quassinoid glycoside was performed for the first time.•Bruceoside A could serve as the precursor of the potent anticancer brusatol in vivo, rather than its direct deglycosylated metabolite bruceosin.•Quassinoid glycosides were proposed to be potential contributors to the anticancer properties of Fructus Bruceae.

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Key words

Quassinoid glycoside,Bruceoside A,Brusatol,Pharmacokinetic study,Intestinal bacteria metabolism

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