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Arsenic trioxide blocked proliferation and cardiomyocyte differentiation of human induced pluripotent stem cells: Implication in cardiac developmental toxicity

Zhengyi Bao,Zhenbo Han,Bo Zhang, Ying Yu,Zihang Xu,Wenya Ma,Fengzhi Ding,Lai Zhang,Meixi Yu,Shenzhen Liu,Mengyu Jin,Gege Yan,Qi Huang,Xiuxiu Wang, Bingjie Hua, Fan Yang,Yuan Li,Yu Liu,Naufal Zagidullin, Katherine Carvalho

Toxicology Letters（2019）

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Abstract
•Indicating the toxicity of ATO in cardiomyocytes differentiation.•Finding that ATO blocked cardiomyocyte differentiation, induced apoptosis and cell growth arrest.•Providing safety guidence for the clinical application of ATO.
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ATO,hiPSCs,APL,hPSCs,hESCs,PBS,EdU,CVPCs,CM,GAPDH,EOMES,MESP-1,TBX-5,GATA-4
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