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Macrophage-Specific IκB Kinase α Contributes to Ventricular Remodelling and Dysfunction After Myocardial Infarction.

Yide Cao,Shuai He,Zhonghao Tao,Wen Chen,Yueyue Xu,Peisheng Liu,Rui Wang,Jianfeng Wu,Liangpeng Li,Xin Chen

Canadian Journal of Cardiology（2019）

Cited 9|Views19
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Abstract
Overall, our data identified IKKɑ in the heart as a novel mediator that protected the heart from a severe inflammatory response and attenuated ventricular remodelling after MI by negatively regulating macrophage polarization to the M1 phenotype. Therefore, IKKα may serve as a potential therapeutic target for treatment after MI.
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Key words
myocardial infarction,ventricular remodelling,macrophage-specific
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