Identification of a miniature Sae2/Ctp1/CtIP ortholog from Paramecium tetraurelia required for sexual reproduction and DNA double-strand break repair.

Julia Godau,Lorenza P Ferretti,Anika Trenner,Emeline Dubois,Christine von Aesch,Antoine Marmignon,Lauriane Simon,Aurélie Kapusta,Raphaël Guérois,Mireille Bétermier,Alessandro A Sartori

DNA Repair（2019）

引用 6|浏览24

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摘要

•Paramecium CtIP constitutes the smallest known ortholog of the Sae2/CtIP family.•Paramecium CtIP is required for the repair of Spo11-induced breaks during meiosis.•CtIP proteins utilize a highly conserved RHR motif for DNA-binding.•The RHR motif of human CtIP supports its accumulation at damage chromatin.•Mutation of the human CtIP-RHR motif confers DSB resection and repair defects.

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关键词

Paramecium tetraurelia,CtIP,Meiosis,DNA double-strand breaks,Homologous recombination,DNA end resection

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