Discovery of pyridoxal reductase activity as part of human vitamin B6 metabolism.
Biochimica et Biophysica Acta (BBA) - General Subjects(2019)
摘要
•Pyridoxine strongly accumulates in CSF of PLP-treated patients, thus suggesting the existence of a PN-forming enzyme;•Our in vitro studies show that all mammalian cell lines tested reduce PL to PN in a time- and dose-dependent manner;•We expand the number of enzymes with a role in human vitamin B6 metabolism;•PL reductase(s) may play an important role in limiting the intracellular accumulation of PL and PLP.
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关键词
Vitamin B6 vitamers,Pyridoxal reductase,Vitamin B6 salvage pathway,KCNAB2,AKR1B1 and AKR1B10
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