Neutral sphingomyelinase increases and delocalizes in the absence of Toll-Like Receptor 4: a new insight for MPTP Neurotoxicity.

Elisabetta Albi,Samuela Cataldi,Michela Codini,Giuseppina Mariucci,Andrea Lazzarini,Maria Rachele Ceccarini,Ivana Ferri, Maria Elena Laurenti,Cataldo Arcuri,Federica Patria,Tommaso Beccari,Carmela Conte

Prostaglandins & Other Lipid Mediators（2019）

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摘要

•The lack of TLR 4 increases the neutral sphingomyelinase expression and activity.•Neutral sphingomyelinase markedly delocalizes in the absence of TLR4.•TLR4 deficiency also affects both heavy neurofilaments and glial fibrillary protein.

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关键词

CNS,GA5,MSA,MPTP,PD,SM,SMase,aSMase,alkSMase,nSMase,SN,TLRs,TH,TLR4 KO,WT

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