TARBP2 inhibits IRF7 activation by suppressing TRAF6-mediated K63-linked ubiquitination of IRF7.
Molecular Immunology（2019）
Abstract
•IRF7 is essential in IFN-β production.•TRAF6 links the upstream receptor molecule MAVS to interferon regulatory factors (IRFs) downstream.•TARBP2 impairs the association with TRAF6 of IRF7.•TARBP2 negatively regulates IRF7-induced IFNβ production upon viral stimulation.
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Key words
IRF7,TRAF6,TARBP2,Ubiquitination,Phosphorylation
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