IFN-γ Promotes Epithelial-Mesenchymal Transition and the Expression of PD-L1 in Pancreatic Cancer.

Daisuke Imai,Tomoharu Yoshizumi,Shinji Okano,Shinji Itoh,Toru Ikegami,Noboru Harada,Shinichi Aishima,Yoshinao Oda,Yoshihiko Maehara

Journal of Surgical Research（2019）

引用 49|浏览10

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摘要

Strong correlations were observed between PD-L1 expression, EMT, and the immunosuppressive tumor microenvironment. Targeting STAT1 combined with PD-1/PD-L1 immunotherapy may improve outcomes for patients with PDA.

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关键词

Pancreatic cancer,Programmed cell death ligand 1,Epithelial-mesenchymal transition,Interferon gamma

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