Widespread clinical use of simethicone, insoluble lubricants, and tissue glue during endoscopy: A call to action for infection preventionists.

•Visual inspections detected oily, tacky, viscous, and opaque residues on endoscopes.•Endoscopists used simethicone, cooking spray, silicone spray, and tissue glue.•These products are insoluble and cannot be removed by reprocessing technicians.•Infection preventionists should assess risks related to off-label product use.•New policies may be needed to support procedural success and effective reprocessing.