The Scavenger Receptor CD68 Regulates Platelet Mediated Oxidized Low-Density Lipoprotein (oxLDL) Deposition in Atherosclerotic Vessels at an Early Stage of Atherosclerosis in LDLR/ApoBec Mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2019）
Abstract
Platelets contribute to increased tissue oxLDL in the aortic wall but not in peripheral blood. CD68 seems to play a role in the oxLDL metabolism in the vessel wall at early stages of atherosclerosis. FcIgG2-FL-CD68 could serve as a novel therapeutic option to modify the oxLDL content in the vessel wall.
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Key words
Atherosclerosis,CD68,Oxidized low-density lipoprotein (oxLDL),Platelets
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