Involvement of mitogen-activated protein kinase pathways in ferrous iron-induced aquaporin-4 expression in cultured astrocytes.
NeuroToxicology(2019)
摘要
•Fe2+ has distinctive toxic effects and increases AQP4 expression in astrocytes.•Inhibiting oxidative stress reduces Fe2+-induced astrocyte death.•Inhibition of oxidative stress diminishes Fe2+-induced AQP4 upregulation.•Inhibiting MAPKs activation reduces Fe2+-induced astrocyte death.•Inhibition of MAPKs activation decreases Fe2+-induced AQP4 upregulation.
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关键词
Aquaporin-4,Ferrous iron,Astrocyte,Oxidative stress,Mitogen-activated protein kinases
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